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ResearchHome > Research >Antibiotic Side Effects

Antibiotic Side Effects and Symptoms of Cystitis

antibiotics medical implications

Antibiotics

Antibiotics have saved millions of lives. Before the advent of penicillin, infections were a leading cause of death. In 1900, the leading causes of death were pneumonia, tuberculosis (TB), diarrhoea and enteritis, which along with diphtheria caused a third of all deaths. Since penicillin was introduced in the 1940s, scientists have developed more than 150 antibiotics to fight the spread of infectious diseases.

That antibiotics were seen to cure previously fatal illnesses led doctors and the public to trust them as ‘miracle drugs’ and in most developed countries, antibiotics are still the second most used drug after pain killers. Most people are familiar with broad spectrum antibiotics- ones that can kill many different types of bacteria and narrow spectrum antibiotics - one that kills a targeted or a small variety of germs.

But although antibiotics have saved millions of lives, the overuse/ misuse of antibiotics has created unforeseen problems.

Overuse

Antibiotics can't distinguish between the "good" and the "bad" bacteria. As is now understood, there is a delicate balance of billions of bacteria happily co-existing with us inside our digestive tract and in our bodies generally. These helpful bacteria “compete” and create a balance in the large intestine, the small intestine and other areas such as the vagina to protect against fungal infections and other bacteria. They also help us utilise nutrients and bolster our immune systems. When antibiotics are overused or underused (a short course or failure to complete the course prescribed may only kill off weak bacteria, leaving stronger bacteria to emerge later), especially broad-spectrum antibiotics, it can seriously disrupt the normal ecology of the body and render anyone more susceptible to pathogenic (disease causing) bacteria, yeast, viral and parasitic infections.

Overuse creates a deficiency of beneficial bacteria, and a state of dysbiosis. To leave the gut in a state of dysbiosis is to leave the body open to a full range of illnesses since it is generally accepted that a healthy gut is essential for total body health. Everything we eat passes through our intestines, and is processed by the bacteria in the gut for extraction of micronutrients, energy, protein, and soluble fibre. In the event of damaged gut bacteria, we do not get the best of the food we consume, and can end up run down, tired all the time and open long term to illness. Meanwhile stronger pathogens such as clostridium and candida may thrive unopposed.

Resistance

Bacterial resistance to antibiotics is produced by changes in the bacterium’s DNA, called ‘Mutations’. One bacterium with a mutation can survive the antibiotic and go on to reproduce millions more with the same resistance. Not only do they survive, but having survived an antibiotic attack, their structure changes so that the same antibiotic is unlikely to kill them in the future.

The Soil Association state that overuse of antibiotic administration in animals is failing to keep pace with the speed at which bacteria are adapting to resist them. This inevitably leads to resistance and complicates treatment in humans since resistance to available therapies is already established.
In addition, many antibiotics that are not broken down in the body remain active long after being excreted. At present, antibiotics make a considerable contribution to the growing problem of active medical substances circulating in the environment. The potential effects and risks associated with the release of antibiotics and other drugs into the environment are huge. Along with antibiotic over/under use this cannot help but increase levels of multiple antibiotic resistance.

Furthermore, the discovery of new antibiotics could be considered as effectively shelved. Between 1945 and 1968, drug companies invented 13 new categories of antibiotics whereas between 1968 and today, only two new categories of antibiotics have emerged.

Year introduced Class of drug:

1935 Sulphonamides
1941 Penicillins
1944 Aminoglycosides
1945 Cephalosporins
1949 Chloramphenicol
1950 Tetracyclines
1952 Macrolides/lincosamides/streptogramins
1956 Glycopeptides
1957 Rifamycins
1959 Nitroimidazoles
1962 Quinolones
1968 Trimethoprim
2000 Oxazolidinones
2003 Lipopeptides


Antibiotics known as flouroquinolones have more recently been associated with some or all of the following adverse drug reactions:

Tendonitis, Tendon Rupture, Tendon, Ligament, Joint and Muscle Damage
Vision Damage, Hearing Loss, Taste Perversion
Peripheral Neuropathy (Tingling, burning sensation)
Insomnia, Nightmares, Anxiety Attacks, Depersonalization, Cognitive Disorders
Brain, Heart, Liver, Kidney, Pancreas, Blood and Endocrine Disorders
Severe Psychotic Reactions, Suicidal Thoughts or Actions
Gastrointestinal Damage

Antibiotics & Cystitis

Most people, when they suffer their first few episodes of cystitis, go to the doctors and are prescribed antibiotics. Initially, the antibiotics can be very effective, especially if you have never had cystitis before. However, with every additional infection, that particular antibiotic is likely to become less effective, as the bacteria builds up resistance.

Therefore, every time you have another episode of cystitis, it tends to be worse than the time before, and then you have a real dilemma. Doctors, who are naturally and correctly wary of prescribing antibiotics, are unlikely to want to give you a more powerful dose, which means that some of the infection is likely to survive, effectively allowing the E.coli to develop resistance, until standard antibiotics like trimethoprim will no longer work. Meanwhile, your episodes of cystitis last longer and longer, and they are likely to begin causing kidney damage, and a lot of persistent pain.
At this point (in the absence of Waterfall D-Mannose®) you will need more powerful broad-spectrum antibiotics to try to solve the problem, and at first these will work. However, the E.coli continues its process of resistance until stronger and stronger broad-spectrum antibiotics are required to kill the infections, and these cause their own particular problems.

In a study to test the effectiveness of three major antibiotics used to treat cystitis (Hooton et al, 1995) the most effective was found at that time (but no longer) to be Trimethoprim-sulphamethoxazole. We are using this early study simply to explore previously identified problems.

"Trimethoprim-sulphamethoxazole proved to be the best treatment, with 82% of women cured at the six-week visit, and with the lowest remaining incidence of vaginal E coli (21%). Adverse events were reported by 35% of patients treated with trimethoprim-sulphamethoxazole, similar to other treatments." 

Comparing Waterfall D-Mannose with Trimethoprim-sulphamethoxazole:

  Trimethoprim-sulphamethoxazole Waterfall D-Mannose
Effectiveness 82% 90%
Adverse effects reported 35% 0%

 

The presence of E.coli after using Waterfall D-Mannose is not known, but what is known is that if you take Waterfall D-Mannose, even after being treated for cystitis with strong antibiotics over an extended period, a huge amount of E.coli is flushed out of your urinary tract. This strongly suggests that many fewer people will be left with E.coli after taking Waterfall D-Mannose, than after taking antibiotics. And we know from a huge amount of user feedback that Waterfall D-Mannose prevents recurrence of the problem in most cases. The longer you've been taking it - the less often threats of cystitis occur, so it does seem to make the bladder very healthy over time.

 

Waterfall D-Mannose

Discover Waterfall D-Mannose...

If you suffer from bladder pain or urinary tract infections, Waterfall Dmannose is the fast and all natural way to treat cystitis.

Antibiotic side-effects

As a general rule, the stronger the antibiotic you take, the worse the side effects. The side effects of broad-spectrum antibiotics, and in particular Fluoroquinolone-based antibiotics such as Ciprofloxacin, can include, but are not limited to the following (these reported effects are freely available): 

Cardiovascular

Heart attack, heart murmur, palpitations, angina, cerebral thrombosis, sudden death on first dose.

Nervous System

Convulsive seizures, psychosis, depression, hallucinations, paranoia, insomnia, nightmares, dizziness.

Gastrointestinal

Liver failure, jaundice, gastrointestinal bleeding, diarrhoea, ulcerative colitis, burst intestine, vomiting, constipation.

Muscles and Bones

Tendon seizure, tendon bursting and ripping, jaw, arm or back pain, joint stiffness, neck and chest pain, aching all over, gout.

Kidneys and Urinary tract

Kidney failure, calcification in kidneys, urethral bleeding, severe thrush, vaginitis.

Respiratory:

Respiratory arrest, blood clotting in lungs, shortness of breath, pulmonary oedema, hiccough.

Skin/Hypersensitivity:

Anaphylactic shock, skin sloughing (falling off), dermatitis, skin death, vasculitis, angioedema, swelling of the lips, eyes, or face, fever, chills, going purple.

Sensory disturbances:

Blurred vision, eye pain, disturbed vision, hearing loss, dizziness, tinnitus, involuntary eye movements, and altered sense of taste.

 

Here's an extract from a clinical trial outlined on http://www.rxlist.com/cipro-side-effects-drug-center.htm

"In this trial, the overall incidence rates of adverse events regardless of relationship to study drug and within 6 weeks of treatment initiation were 41% (138/335) in the ciprofloxacin group versus 31% (109/349) in the comparator group. The most frequent events were gastrointestinal: 15% (50/335) of ciprofloxacin patients compared to 9% (31/349) of comparator patients. Serious adverse events were seen in 7.5% (25/335) of ciprofloxacin-treated patients compared to 5.7% (20/349) of control patients. Discontinuation of drug due to an adverse event was observed in 3% (10/335) of ciprofloxacin-treated patients versus 1.4% (5/349) of comparator patients. Other adverse events that occurred in at least 1% of ciprofloxacin patients were diarrhoea 4.8%, vomiting 4.8%, abdominal pain 3.3%, accidental injury 3.0%, rhinitis 3.0%, dyspepsia 2.7%, nausea 2.7%, fever 2.1%, asthma 1.8% and rash 1.8%."

Not all of the observed side effects are listed.

Immune system effects

When you take antibiotics, your immune system can become weakened, meaning that you are more prone to infection than before you took the antibiotics. So the infection may be killed, but you get re-infected easily. When this is combined with re-infection with a more resistant strain of the bacteria that caused the original infection, it can be very difficult to deal with.

Broad-spectrum antibiotics have even more potential to damage your immune system, so as time goes on, and you become infected with more and more resistant strains of (usually) E.coli, you find it not only harder to fight off each infection, but harder to prevent yourself becoming re-infected. Eventually, no matter what you do, even if you are clean to the point of obsession (like almost everyone who has suffered repeated episodes of cystitis) you still get infected. This is often because the bacteria have been living in your gut or urinary tract, just waiting for your immune system to be at its lowest, allowing them to breed rapidly and take over your body once again.

Thrush - Candida Albicans

It is well-known that taking antibiotics increases your chances of contracting thrush. As a general rule, the stronger the antibiotic, the worse the episode of thrush you get afterwards. Eventually, the thrush can become as persistent and almost as painful as the cystitis, because the fungus builds up resistance to the treatments you use against it. See coping with thrush

Vasculitis

Vasculitis of varying levels of severity is one of the listed side effects of some broad-spectrum antibiotics commonly used for the treatment of cystitis. It is caused by immune reaction that can disrupt DNA and RNA, and put white blood cells on the attack against your own body. Lupus-like effects are common.
Symptoms can include, but are not limited to:

Skin

Red or purple dots, usually most numerous on the legs. When the spots are larger, about the size of the end of a finger, they are called purpura. Some look like large bruises. These are the most common vasculitis skin lesions, but hives, itchy lumpy rash, and painful or tender lumps can occur. Areas of dead skin can appear as ulcers, small black spots appear at the ends of the finger or around the fingernails and toes, or you may get gangrene of fingers or toes.

Joints

Aching in joints and obvious arthritis with pain, swelling and heat in joints. Deformities resulting from this arthritis are rare.


Brain

Vasculitis in the brain can cause many problems, from mild to severe. They include headaches, behavioural disturbances, confusion, seizures, and strokes. May be fatal.

Peripheral Nerves

Peripheral nerve symptoms may include numbness and tingling (usually in an arm or a leg, or in areas which would be covered by gloves or socks), loss of sensation or loss of strength, particularly in the feet or hands.


Intestines

Vasculitis can cause inadequate blood flow in the intestines, resulting in crampy abdominal pain and bloating. If areas in the wall of the intestine develop gangrene, blood will appear in the stool. If the intestinal wall develops a perforation, surgery may be required.

Heart

Vasculitis may affect the coronary arteries. If it occurs, it can cause a feeling of heaviness in the chest during exertion (angina), which is relieved by rest. Heart attacks rarely occur as a direct result of vasculitis.


Lungs

Vasculitis in lung tissue can cause pneumonia-like attacks with chest x-ray changes that look like pneumonia, and symptoms of fever and cough. Occasionally, inflammation can lead to scarring of lung tissue with chronic shortness of breath.

Eyes

Vasculitis can involve the small blood vessels of the retina. Sometimes, vasculitis of the eyes causes no symptoms. Usually, however, there is visual blurring which comes on suddenly and stays, or a person may even lose a portion of their vision. In temporal arteritis, there is sudden loss of part or all of the vision in one eye, usually accompanied by severe headache.

Distribution in the body

From a Ciprofloxacin Product Label:

"After oral administration, ciprofloxacin is widely distributed throughout the body. Tissue concentrations often exceed serum concentrations in both men and women, particularly in genital tissue including the prostate. Ciprofloxacin is present in active form in the saliva, nasal and bronchial secretions, mucosa of the sinuses, sputum, skin blister fluid, lymph, peritoneal fluid, bile, and prostatic secretions. Ciprofloxacin has also been detected in lung, skin, fat, muscle, cartilage, and bone. The drug diffuses into the cerebrospinal fluid (CSF); however, CSF concentrations are generally less than 10% of peak serum concentrations. Low levels of the drug have been detected in the aqueous and vitreous humors of the eye."

Finally

Antibiotics have a major and truly welcome role to play in human health, but the conclusion must surely be reached that they should be used conservatively with a view to avoiding potential and universal hazards that go far beyond the individual instance of use to turn up in food, water and increased bacterial resistance such as is seen with MRSA and EBSL (ESBL refers to an antibiotic-resistance enabling enzyme that the bacteria are producing, as a means of protecting themselves against attack.)

Evidence, Research & Further Reading

Ciproflaxin product label: http://www.fda.gov/downloads/drugs/emergencypreparedness/bioterrorismanddrugpreparedness/ucm130802.pdf

Ciproflaxin side effects: http://www.rxlist.com/cipro-side-effects-drug-center.htm

Fuchs, S., Simon, Z., Brezis, M. (1994) ‘Fatal hepatic failure associated with ciprofloxacin’, The Lancet, vol. 242, pp.738-739. http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(94)91624-1/fulltext

Hooper, D.C. (2001) ‘Emerging Mechanisms of Fluoroquinolone Resistance’, Emerg Infect Dis, vol. 7, no. 2, pp.337-41. http://www.ncbi.nlm.nih.gov/pubmed/11294736

Hooton, T.M., Winter, C., Tiu, F., & Stamm, W.E. (1995) ‘Randomized comparative trial and cost analysis of 3-day antimicrobial regimens for treatment of acute cystitis in women’, Journal of the American Medical Association, vol 273, pp.41-5. http://www.ncbi.nlm.nih.gov/pubmed/7654268

Howard, S.J., Catchpole, M., Watson, J. & Davies, S. (2013) ‘Antibiotic Resistance: global response needed’ , The Lancet Infectious Diseases, vol 13, no. 12, pp.1001 – 1003.  http://www.thelancet.com/journals/laninf/article/PIIS1473-3099(13)70195-6/fulltext?

Osborn, H.M.I. & Gridley, J.J. (2000) ‘Recent advances in the construction of beta-D-mannose and beta-D-mannosamine linkages’, J. Chem. Soc., Perkin Trans, vol 1, pp.1471-1491. http://pubs.rsc.org/en/Content/ArticleLanding/2000/P1/a909165c#!divAbstract

Sweet RL, Gibbs RS (1995) ‘Urinary tract infection’, in Infectious Disease of the Female Genital Tract. 3rd ed., pp.429-64, Baltimore: Lippincott Williams & Wilkins.

 

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